Targeting Two Different Chemicals in the Brain

In Alzheimer's disease, there are two types of FDA-approved medications used to help treat the symptoms of the disease: cholinesterase inhibitors and NMDA-receptor antagonists. Since each of these drugs targets a different chemical pathway in the brain that affects memory and learning,^1-5 they may be more effective when taken together in combination.⁶

The two types of medications used to treat Alzheimer's are:

• Cholinesterase inhibitors (AChEIs) reduce the breakdown of acetylcholine, a chemical in the brain important for learning and memory. People with Alzheimer's disease don't make enough acetylcholine and this can affect their memory and thinking. Drugs in this class include Aricept^® (donepezil)^*, Exelon^® (rivastigmine) and Razadyne^® (galantamine).
• NMDA-receptor antagonists target glutamate, another chemical in the brain involved in learning and memory. Abnormal activity related to glutamate in the brain may lead to Alzheimer's disease symptoms. The only drug in this class is called Namenda^® (memantine HCl).^**

As a caregiver, it's important to stay informed about all the ways you can help enhance the care and treatment of your loved one — this includes understanding the benefits of combination therapy. Enroll now in the Combination Care for Alzheimer's Program for a personalized Doctor Discussion Guide with helpful tips on talking to your doctor about enhancing your loved one's treatment.